Yap1 regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin
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چکیده
Background: Hippo-Yap signaling pathway is one of the critical pathways regulating cell proliferation, differentiation and apoptosis. Results: Knockdown of endogenous Yap1 impairs VSMC proliferation and enhances VSMC contractile phenotype by promoting the association of the myocardin/ SRF/CArG complex. Conclusion: Yap1 signaling pathway is a central regulator of phenotypic switch of VSMCs Significance: Phenotypic switch of VSMCs and vessel injury response can be controlled by modulation of Hippo-Yap signaling. SUMMARY
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تاریخ انتشار 2012